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Activation of endogenous angiotensin converting enzyme 2 prevents early injuries induced by hyperglycemia in rat retina BJMBR
Foureaux,G.; Nogueira,B. S.; Coutinho,D. C. O.; Raizada,M. K.; Nogueira,J. C.; Ferreira,A. J..
Diabetic retinopathy (DR) is a serious complication of diabetes mellitus that may result in blindness. We evaluated the effects of activation of endogenous angiotensin converting enzyme (ACE) 2 on the early stages of DR. Rats were administered an intravenous injection of streptozotocin to induce hyperglycemia. The ACE2 activator 1-[[2-(dimethylamino) ethyl] amino]-4-(hydroxymethyl)-7-[[(4-methylphenyl) sulfonyl] oxy]-9H-xanthone 9 (XNT) was administered by daily gavage. The death of retinal ganglion cells (RGC) was evaluated in histological sections, and retinal ACE2, caspase-3, and vascular endothelial growth factor (VEGF) expressions were analyzed by immunohistochemistry. XNT treatment increased ACE2 expression in retinas of hyperglycemic (HG) rats...
Tipo: Info:eu-repo/semantics/article Palavras-chave: ACE2 activation; Angiotensin-(1-7); Renin-angiotensin system; Eyes; Diabetic retinopathy.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001201109
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