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Analgesic and anti-arthritic effect of Corallocarpus epigaeus ABCL
Uthrapathy,Subashini; Shabi,Mohamed M; Krishnamoorthy,Gayathri; Ravindhran,Dhevi; Rajamanickam,Victor G; Pillay Dubey,Govindha.
Rheumatoid arthritis is a chronic inflammatory joint disease associated with the development of oxidative stress and inflammation. The safety and efficacy profile of 85% methanolic extract of Corallocarpus epigaeus (CE) was evaluated in the present study. In safety profile LD50 value was determined by carrying out an acute toxicity study. In efficacy profile, the analgesic activity was evaluated by both hot plate and tail immersion tests. The anti-inflammatory activity was assessed by carrageenan-induced paw edema and anti-arthritic effect by complete Freund's adjuvant induced arthritis. Phytochemical screening of different CE extracts and quantitative analysis of both raw herb and 85% methanolic extract have been also carried out. The methanolic extract...
Palavras-chave: Corallocarpus epigaeus; Analgesic; Anti-inflammatory and antioxidant properties; Hot plate; Tail immersion; Carrageenan; Complete Freund's adjuvant.
Ano: 2011 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572011000400006
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