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| Bourhy, Herve; Nakoune, Emmanuel; Hall, Matthew; Nouvellet, Pierre; Lepelletier, Anthony; Talbi, Chiraz; Watier, Laurence; Holmes, Edward C.; Cauchemez, Simon; Lemey, Philippe; Donnelly, Christl A.; Rambaut, Andrew. |
| The development of novel approaches that combine epidemiological and genomic data provides new opportunities to reveal the spatiotemporal dynamics of infectious diseases and determine the processes responsible for their spread and maintenance. Taking advantage of detailed epidemiological time series and viral sequence data from more than 20 years reported by the National Reference Centre for Rabies of Bangui, the capital city of Central African Republic, we used a combination of mathematical modeling and phylogenetic analysis to determine the spatiotemporal dynamics of rabies in domestic dogs as well as the frequency of extinction and introduction events in an African city. We show that although dog rabies virus (RABV) appears to be endemic in Bangui, its... |
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| Ano: 2016 |
URL: http://archimer.ifremer.fr/doc/00326/43717/43161.pdf |
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| Talbi, Chiraz; Lemey, Philippe; Suchard, Marc A.; Abdelatif, Elbia; Elharrak, Mehdi; Nourlil, Jalal; Abdellah, Faouzi; Echevarria, Juan E.; Moron, Sonia Vasquez; Rambaut, Andrew; Campiz, Nicholas; Tatem, Andrew J.; Holmes, Edward; Bourhy, Hervé. |
| Understanding the role of humans in the dispersal of predominately animal pathogens is essential for their control. We used newly developed Bayesian phylogeographic methods to unravel the dynamics and determinants of the spread of dog rabies virus (RABV) in North Africa. Each of the countries studied exhibited largely disconnected spatial dynamics with major geo-political boundaries acting as barriers to gene flow. Road distances proved to be better predictors of the movement of dog RABV than accessibility or raw geographical distance, with occasional long distance and rapid spread within each of these countries. Using simulations that bridge phylodynamics and spatial epidemiology, we demonstrate that the contemporary viral distribution extends beyond that... |
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| Ano: 2010 |
URL: http://archimer.ifremer.fr/doc/00139/24992/23090.pdf |
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