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| Pinheiro,Valéria G. F.; Ramos,Lysiane M. A.; Monteiro,Helena S. A.; Barroso,Elizabeth C.; Bushen,Oluma Y.; Façanha,Mônica C.; Peloquin,Charles A.; Guerrant,Richard L.; Lima,Aldo A. M.. |
| Low antimycobacterial drug concentrations have been observed in tuberculosis (TB) patients under treatment. The lactulose/mannitol urinary excretion test (L/M), normally used to measure intestinal permeability, may be useful to assess drug absorption. The objective of this research was to study intestinal absorptive function and bioavailability of rifampin and isoniazid in TB patients. A cross sectional study was done with 41 patients and 28 healthy controls, using the L/M test. The bioavailabilities of rifampin (R) and isoniazid (H) were evaluated in 18 patients receiving full doses. Urinary excretion of mannitol and lactulose, measured by HPLC, was significantly lower in TB patients. The serum concentrations of the drugs were below the expected range for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pulmonary tuberculosis; Intestinal permeability; Rifampin and isoniazid intestinal malabsorption; M. tuberculosis resistance. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600003 |
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