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| Levy,A.; Rangel-Santos,A.; Torres,L.C.; Silveira-Abreu,G.; Agena,F.; Carneiro-Sampaio,M.. |
| The thymus is a primary lymphoid organ responsible for the maturation of T cells as well as the immunological central tolerance. It is in the antenatal period and infancy that it plays its major role. In clinical practice, T cell receptor excision circles (TRECs) are considered a direct and reliable measure of the thymic function. TRECs are a by-product of DNA formation in gene rearrangement of T cell receptors. They are stable and they do not duplicate during mitosis, representing the recent emigrant T cells from the thymus. Despite their importance, TRECs have been neglected by physicians and there is a lack of data regarding thymic function during infancy of healthy children. In order to evaluate thymic function in the first years of life, we propose... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Human thymus; TRECs; Thymic function; Infants. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000700601 |
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