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Alginate/hydrophobic HPMC (60M) particulate systems: new matrix for site-specific and controlled drug delivery BJPS
Ghosal,Kajal; Ray,Sarbani Dey.
This study aimed to obtain site-specific and controlled drug release particulate systems. Some particulates were prepared using different concentrations of sodium alginate (Na-Alg) alone and others were formulated using different proportions of Na-Alg with hydroxypropyl methylcellulose (HPMC) stearoxy ether (60M viscosity grade), a hydrophobic form of conventional HPMC, using diclofenac potassium (DP) by ion-exchange methods. Beads were characterized by encapsulation efficiency, release profile, swelling, and erosion rate. The suitability of common empirical (zero-order, first-order and Higuchi) and semi-empirical (Ritger-Peppas and Peppas-Sahlin) models was studied to describe the drug release profile. The Weibull model was also studied. Models were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drugs/release particulate systems; Drugs/release profile; Hydroxypropyl methylcellulose stearoxy ether; Sodium alginate; Direct fitting; Case II transport; Beads/characterization; Beads/release kinetics.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400021
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Effect of cross-linked biodegradable polymers on sustained release of sodium diclofenac-loaded microspheres BJPS
Saha,Avik Kumar; Ray,Sarbani Dey.
The objective of this study was to formulate an oral sustained release delivery system of sodium diclofenac(DS) based on sodium alginate (SA) as a hydrophilic carrier in combination with chitosan (CH) and sodium carboxymethyl cellulose (SCMC) as drug release modifiers to overcome the drug-related adverse effects and to improve bioavailability. Microspheres of DS were prepared using an easy method of ionotropic gelation. The prepared beads were evaluated for mean particle size, entrapment efficiency, swelling capacity, erosion and in-vitro drug release. They were also subjected to various studies such as Fourier Transform Infra-Red Spectroscopy (FTIR) for drug polymer compatibility, Scanning Electron Microscopy for surface morphology, X-ray Powder...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Alginate beads/preparation; Alginate beads/evaluation; Drugs/sustained release; Interpenetrating network; Sodium diclofenac/microsphere; Sodium diclofenac/sustained release; Ionotropic gelation.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400028
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