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Amaral,A.V.C.; Silva,G.A.; Costa,A.P.A.; Oliveira,K.S.; Jordão,P.; Ribeiro,A.P.; Renzo,R.; Laus,J.L.. |
Sildenafil citrate is a type-5 phosphodiesterase inhibitor (PDE-5), able to inhibit type-6 phosphodiesterase (PDE-6) as well, providing clinical benefits and paraeffects, some of them potentially related to the retina. The effects of the sildenafil on the retrobulbar and retinal circulation were studied in 27 adult male rabbits of the White New Zealand breed. The electric activity of the retina was evaluated before and at the end of the treatments, and immunohistochemistry studies were conducted. An amplitude increase of the b wave was found in the mixed response of cones and rods after 7 days of treatment with sildenafil citrate. However, in the other evaluations and periods, the values did not differ from the basal ones. Through immunohistochemistry, no... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rabbit; Sildenafil citrate; Electroretinography; Immunohistochemistry. |
Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352015000601589 |
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Abreu,T.G.M.; Feliciano,M.A.R.; Renzo,R.; Kobashigawa,K.K.; Chacaltana,F.D.Y.C.; Crivelaro,R.M.; Silveira,C.P. B.; Cruz,N.R.N.; Aldrovani,M.; Maronezi,M.C.; Silva,P.A.; Thiesen,R.; Laus,J.L.. |
ABSTRACT Eyes from brachycephalic dogs were studied by acoustic radiation force impulse (ARFI) elastography to establish quantitative and qualitative reference values related to the shape and rigidity of some ocular structures. Eighty-four eyes from 42 adult brachycephalic dogs were included in this study. Animals were subjected to physical, laboratory, and ophthalmic examinations. Following confirmation of good health, the dogs were subjected to ultrasonography and ARFI elastography, emphasizing the optic nerve, ciliary body, and lens. On qualitative elastography, homogeneous characteristics were observed on the ciliary body and optic nerve. Aqueous and vitreous humors were visualized as mosaic-like images. Quantitative elastography showed the mean optic... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Canine; Ocular structures; Ultrasound. |
Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000401045 |
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