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Self-reported cancer family history is a useful tool for identification of individuals at risk of hereditary cancer predisposition syndrome at primary care centers in middle-income settings: a longitudinal study Genet. Mol. Biol.
Flória-Santos,Milena; Lopes-Júnior,Luís Carlos; Alvarenga,Larissa de Melo; Ribeiro,Mayara Segundo; Ferraz,Victor Evangelista de Faria; Nascimento,Lucila Castanheira; Pereira-da-Silva,Gabriela.
Abstract Analysis of cancer family history (CFH) offers a low-cost genetic tool to identify familial cancer predisposition. In middle-income settings, the scarcity of individual records and database-linked records hinders the assessment of self-reported CFH consistency as an indicator of familial cancer predisposition. We used self-reported CFH to identify those families at risk for hereditary cancer syndromes in community-based primary care centers of a low-income Brazilian area. We also evaluated the consistency of the information collected by reassessing CFH five years later. We interviewed 390 families and constructed their pedigrees for genetic cancer risk assessment. We found 125 families affected by cancer, 35.2% with moderate to high risk of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Genetic predisposition to disease; Risk factors; Neoplasms; Family; Pedigree.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000200178
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