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| Carmo,R.A.; Oliveira,G.C.; Guimarães,M.D.C.; Oliveira,M.S.; Lima,A.A.; Buzek,S.C.; Corrêa-Oliveira,R.; Rocha,M.O.C.. |
| We determined and analyzed risk factors of hepatitis C virus (HCV)-infected Brazilian hemophiliacs according to their virological, clinical and epidemiological characteristics. A cross-sectional and retrospective study of 469 hemophiliacs was carried out at a Brazilian blood center starting in October 1997. The prevalence of HCV infection, HCV genotypes and factors associated with HCV RNA detection was determined. The seroprevalence of anti-HCV antibodies (ELISA-3.0) was 44.6% (209/469). Virological, clinical and epidemiological assessments were completed for 162 positive patients. There were seven (4.3%) anti-HCV seroconversions between October 1992 and October 1997. During the same period, 40.8% of the positive anti-HCV hemophiliacs had abnormal alanine... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C virus; HCV genotypes; Hemophilia; Chronic liver disease; Transfusion; Brazil. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500012 |
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| Bahia-Oliveira,L.M.G.; Gomes,J.A.S.; Rocha,M.O.C.; Moreira,M.C.V.; Lemos,E.M.; Luz,Z.M.P.; Pereira,M.E.S.; Coffman,R.L.; Dias,J.C.P.; Cançado,J.R.; Gazzinelli,G.; Corrêa-Oliveira,R.. |
| An apparently paradoxical role for IFN-<FONT FACE="Symbol">g</font> in human Chagas' disease was observed when studying the pattern of cytokine production by peripheral blood mononuclear cells (PBMC) obtained from two groups of chagasic patients after specific stimulation with Trypanosoma cruzi-derived antigens. The groups studied were 1) patients treated with benznidazole during the acute phase of Trypanosoma cruzi infection and 2) chronically infected untreated patients. In the treated group, higher levels of IFN-<FONT FACE="Symbol">g</font> were produced by PBMC from individuals cured after treatment when compared to non-cured patients. In contrast, in the chronically infected group (not treated) higher levels of IFN-<FONT... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Trypanosoma cruzi Chagas' disease cardiomyopathy peripheral blood mononuclear cells (PBMC) cytokines INF-<; FONT FACE=Symbol>; G<; /font>. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100017 |
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