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| Rodrigues,Leticia Norma Carpentieri; Issa,Michelle Georges; Asbahr,Ana Carolina Cavassin; Silva,Marco Aurélio Carvalho; Ferraz,Humberto Gomes. |
| The combined effect of hydroxypropyl-β-cyclodextrin (HPβCD) and polyvinylpyrrolidone (PVP) or sodium carboxymethylcellulose (CMC) on the solubility of pyrimethamine (PYR) was studied. Equimolar PYR-HPβCD solid systems, in the presence or the absence of 0.25% (w/v) PVP or 0.10% (w/v) CMC were prepared by coevaporation or freeze-drying, and characterized by differential scanning calorimetry, X-ray diffraction analysis and dissolution profile. Phase-solubility analysis was used to investigate the interactions in aqueous solution between PYR and HPβCD, in the absence or presence of polymers, which showed a linear increase of PYR solubility depending on the concentration of HPβCD. The presence of polymer did not alter the stoichiometry of the complexes. DSC... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pyrimethamine; HPβCD; Inclusion complexes. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500014 |
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| Rodrigues,Leticia Norma Carpentieri; Tavares,Anna Carollina Moraes; Ferreira,Beatriz Tavares; Reis,Adriana Karla Cardoso Amorim; Katiki,Luciana Morita. |
| Albendazole and fenbendazole are imidazole derivatives that exhibit broad spectrum activity against parasites, but the low solubility of these drugs considerably reduces their effectiveness. Complexation of albendazole and fenbendazole with cyclodextrins (β-cyclodextrin and hydroxypropyl-β-cyclodextrin) in both water and an aqueous solution of polyvinylpyrrolidone (PVP-k30) was studied to determine if it could increase the solubility and dissolution rate of the drugs. In an aqueous solution, β-cyclodextrin increased the solubility of albendazole from 0.4188 to ~93.47 µg mL-1 (223×), and of fenbendazole from 0.1054 to 45.56 µg mL-1 (432×); hydroxypropyl-β-cyclodextrin, on the other hand, increased solubility to ~443.06 µg mL-1 (1058×) for albendazole and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cyclodextrins/pharmacokinetics Benzimidazoles/administration & Dosage Inclusion complexes Cyclodextrin aggregates Drug liberation/drug effects Antiparasitic agents/analysis Albendazole/analysis Fenbendazole/analysis. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100551 |
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