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| Santos,Ed Wilson; Oliveira,Dalila Cunha; Hastreiter,Araceli; Silva,Graziela Batista; Beltran,Jackeline Soares de Oliveira; Rogero,Marcelo Macedo; Fock,Ricardo Ambrósio; Borelli,Primavera. |
| Obesity is a chronic inflammatory disease that affects millions of people worldwide. Most studies observe the effects of a high-fat diet (HFD) in 10-12 weeks. This work investigated the effects induced by a HFD administered for 6 weeks on the nutritional status of mice and some aspects of the inflammatory response in mouse peritoneal macrophages. Male Swiss Webster mice, 2-3 months of age, were fed a control diet or HFD for 6 weeks. After this period, the mice were euthanized, and peritoneal macrophages were collected for immunoassays and assessment of biochemical parameters. A HFD was associated with increased cholesterol, insulin resistance, C-reactive protein (CRP), leptin, and serum resistin levels. Lipopolysaccharide (LPS)- stimulated adipocyte... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: High-fat diet/study; Mice; Macrophages; Metabolic syndrome; NF-kB.. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100548 |
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| Botelho,Patrícia Borges; Fioratti,Cyntia Okoshi; Rogero,Marcelo Macedo; Barroso,Lucia Pereira; Bertolami,Marcelo Chiara; Castro,Inar Alves. |
| The objective of this study was to investigate whether differences in diet and in single-nucleotide polymorphisms (SNPs) found in paraoxonase-1 (PON-1), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), cholesterol ester transfer protein (CETP) and apolipoprotein E (APOE) genes, are associated with oxidative stress biomarkers and consequently with susceptibility of low-density cholesterol (LDL) to oxidation. A multivariate approach was applied to a group of 55 patients according to three biomarkers: plasma antioxidant activity, malondialdehyde and oxidized LDL (oxLDL) concentrations. Individuals classified in Cluster III showed the worst prognoses in terms of antioxidant activity and oxidative status. Individuals classified in Cluster I presented... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diet; Oxidative stress/biomarkers; Single-nucleotide polymorphism (SNPs); Lipoproteins/oxidation; Statins; Apolipoprotein E. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100005 |
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