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RELAGH - the challenge of having a scientific network in Latin America: an account from the presidents Genet. Mol. Biol.
Rojas-Martínez,Augusto; Giraldo-Ríos,Alejandro; Jiménez-Arce,Gerardo; Falcón de Vargas,Aída; Giugliani,Roberto.
Latin America and the Caribbean region make up one of the largest areas of the world, and this region is characterized by a complex mixture of ethnic groups sharing Iberian languages. The area is comprised of nations and regions with different levels of social development. This region has experienced historical advances in the last decades to increase the minimal standards of quality of life; however, several factors, such as concentrated populations in large urban centers and isolated and poor communities, still have an important impact on medical services, particularly genetics services. Latin American researchers have greatly contributed to the development of human genetics and historic inter-ethnic diversity, and the multiplicity of geographic areas...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Latin America and the Caribbean; Human and medical genetics; International organization; Research cooperation; Education.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000200017
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Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer Genet. Mol. Biol.
Borrego-Soto,Gissela; Ortiz-López,Rocío; Rojas-Martínez,Augusto.
Abstract Breast cancer is the most common malignancy in women. Radiotherapy is frequently used in patients with breast cancer, but some patients may be more susceptible to ionizing radiation, and increased exposure to radiation sources may be associated to radiation adverse events. This susceptibility may be related to deficiencies in DNA repair mechanisms that are activated after cell-radiation, which causes DNA damage, particularly DNA double strand breaks. Some of these genetic susceptibilities in DNA-repair mechanisms are implicated in the etiology of hereditary breast/ovarian cancer (pathologic mutations in the BRCA 1 and 2 genes), but other less penetrant variants in genes involved in sporadic breast cancer have been described. These same genetic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Breast cancer; Ionizing radiation; DNA damage; DNA double strand break; DNA repair analysis.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000400420
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