|
|
| Hollenbach,Clarissa Boemler; Stedile,Rafael; Mello,Fabíola Peixoto da Silva; Bing,Rafaela Scheer; Rosa,Patrícia Pisoni da; Rodrigues,Maria Regina Alves; Mello,Fernanda Bastos de; Zanette,Régis Adriel; Mello,João Roberto Braga de. |
| ABSTRACT: Despite the increasing use of oregano ( Origanum vulgare L.) essential oil for therapeutic purposes, pre- and postnatal development of animals offspring exposed to this oil has not yet been evaluated. In line with previous concerns of genotoxicity, in this study adult rats were exposed to different doses of oregano essential oil (3, 9 and 27% vol/vol) during pre-mating, mating, gestation and lactation. Prenatal screening included fetal development and uterine inspection, where the reproductive rate of females such as breeding, pregnancy, delivery, viability and post-implantation loss rate were measured. Postnatal evaluation of rat offspring included motor development, neuroendocrine and behavioral assessment. Body weight of rat dams and signs of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Oregano; Reproductive toxicity; Progeny; Reproduction; Rats. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000100552 |
| |
