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| Rugeles,M.T.; Rincón,B.; Rugeles,C.; Montoya,C.J.; Hernández,M.; Estrada,C.; Olivares,M.M.; Patiño,P.J.. |
| Several primary immunodeficiency diseases affecting the interleukin 12/interferon gamma (IFN-gamma) pathway have been identified, most of them characterized by recurrent and protracted infections produced by intracellular microorganisms, particularly by several species of mycobacteria. In the present study we analyzed the expression of IFN-gamma receptor (IFN-gammaR) and signal transducer and activator of transcription 1 (STAT-1) in 4 children with Mycobacterium tuberculosis infection of uncommon clinical presentation. These molecules were evaluated by flow cytometry and Western blotting in B cells transformed with Epstein-Barr virus and mutations were scanned by single-strand conformational polymorphisms and DNA sequencing. The expression of IFN-gammaR1... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mycobacterial disease; IFN-gamma; IFN-gamma receptor; STAT-1; SSCP-PCR. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000900010 |
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