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Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis BJMBR
Antunes-Rodrigues,J.; Ruginsk,S.G.; Mecawi,A.S.; Margatho,L.O.; Cruz,J.C.; Vilhena-Franco,T.; Reis,W.L.; Ventura,R.R.; Reis,L.C.; Vivas,L.M.; Elias,L.L.K..
Several forebrain and brainstem neurochemical circuitries interact with peripheral neural and humoral signals to collaboratively maintain both the volume and osmolality of extracellular fluids. Although much progress has been made over the past decades in the understanding of complex mechanisms underlying neuroendocrine control of hydromineral homeostasis, several issues still remain to be clarified. The use of techniques such as molecular biology, neuronal tracing, electrophysiology, immunohistochemistry, and microinfusions has significantly improved our ability to identify neuronal phenotypes and their signals, including those related to neuron-glia interactions. Accordingly, neurons have been shown to produce and release a large number of chemical...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypothalamus; Gaseous neuromodulators; Neuropeptides; Endocannabinoids; Glial cells; Neurotransmitters.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400327
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Central actions of glucocorticoids in the control of body fluid homeostasis: Review BJMBR
Ruginsk,S.G.; Lopes da Silva,A.; Ventura,R.R.; Elias,L.L.K.; Antunes-Rodrigues,J..
The involvement of the hypothalamic-pituitary-adrenal axis in the control of body fluid homeostasis has been extensively investigated in the past few years. In the present study, we reviewed the recent results obtained using different approaches to investigate the effects of glucocorticoids on the mechanisms of oxytocin and vasopressin synthesis and secretion in response to acute and chronic plasma volume and osmolality changes. The data presented here suggest that glucocorticoids are not only involved in the mechanisms underlying the fast release but also in the transcriptional events that lead to decreased synthesis and secretion of these neuropeptides, particularly oxytocin, under diverse experimental conditions of altered fluid volume and tonicity. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Corticosterone; Vasopressin; Oxytocin; Endocannabinoid; Glutamate; NFκB.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100010
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