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Regulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II molecules BJMBR
Bacellar,O.; Russo,C.; Carvalho,E.M..
It has been shown that HLA class I molecules play a significant role in the regulation of the proliferation of T cells activated by mitogens and antigens. We evaluated the ability of mAb to a framework determinant of HLA class I molecules to regulate T cell proliferation and interferon gamma (IFN-<FONT FACE="Symbol">g</FONT>) production against leishmania, PPD, C. albicans and tetanus toxoid antigens in patients with tegumentary leishmaniasis and healthy subjects. The anti-major histocompatibility complex (MHC) mAb (W6/32) suppressed lymphocyte proliferation by 90% in cultures stimulated with <FONT FACE="Symbol">a</FONT>CD3, but the suppression was variable in cultures stimulated with leishmania antigen. This suppression ranged from...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HLA class I tegumentary leishmaniasis modulation of T cell response by HLA class I interferon-<; FONT FACE=Symbol>; G<; /FONT>; And HLA class I soluble antigen and HLA class I.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001200010
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