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Composition and biological activities of the aqueous extracts of three scleractinian corals from the Mexican Caribbean: Pseudodiploria strigosa, Porites astreoides and Siderastrea siderea J. Venom. Anim. Toxins incl. Trop. Dis.
García-Arredondo,Alejandro; Rojas-Molina,Alejandra; Ibarra-Alvarado,César; Lazcano-Pérez,Fernando; Arreguín-Espinosa,Roberto; Sánchez-Rodríguez,Judith.
Abstract Background: Scleractinian corals (stony corals) are the most abundant reef-forming cnidarians found in coral reefs throughout the world. Despite their abundance and ecological importance, information about the diversity of their toxins and their biological activities is very scarce. In this study, the chemical composition and the biological activities of the aqueous extracts of Pseudodiploria strigosa, Porites astreoides and Siderastrea siderea, three scleractinian corals from the Mexican Caribbean, have been assessed for the first time. Methods: Toxicity of the extracts was assessed in crickets; the presence of cytolysins was detected by the hemolysis assay; the vasoconstrictor activity was determined by the isolated rat aortic ring assay; the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scleractinia; Pseudodiploria strigosa; Porites astreoides; Siderastrea siderea; Toxicity; Hemolysis; Vasoconstriction; Nociceptive response.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100323
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Toxins from the Caribbean sea anemone Bunodeopsis globulifera increase cisplatin-induced cytotoxicity of lung adenocarcinoma cells J. Venom. Anim. Toxins incl. Trop. Dis.
Monroy-Estrada,Heidi I; Chirino,Yolanda I; Soria-Mercado,Irma E; Sánchez-Rodríguez,Judith.
Background Lung cancer causes 1.4 million deaths worldwide while non-small-cell lung cancer (NSCLC) represents 80-85% of the cases. Cisplatin is a standard chemotherapy against this type of cancer; however, tumor cell resistance to this drug limits its efficacy. Sea anemones produce compounds with pharmacological activities that may be useful for augmenting cisplatin efficacy. This study aimed to evaluate the pharmacological activities of crude venom (CV) from the sea anemone Bunodeopsis globulifera and four derived fractions (F1, F2, F3 and F4) to test their increase efficiency cisplatin cytotoxicity in human lung adenocarcinoma cells. Results Pre-exposure to CV, F1 and F2 fractions increases cisplatin cytotoxicity in human lung adenocarcinoma cells under...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cnidaria; Pharmacology; Human lung cancer cells; Cytotoxicity assay; Cisplatin efficacy.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100308
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