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| SEROV,OLEG; MATVEEVA,NATALIA; KUZNETSOV,SERGEY; KAFTANOVSKAYA,ELENA; MITTMANN,JOSANE. |
| The properties of embryonic hybrid cells obtained by fusion of embryonic stem (ES) or teratocarcinoma (TC) cells with differentiated cells are reviewed. Usually, ES-somatic or TC-somatic hybrids retain pluripotent capacity at high levels quite comparable or nearly identical with those of the pluripotent partner. When cultured in vitro, ES-somatic- and TC-somatic hybrid cell clones, as a rule, lose the chromosomes derived from the somatic partner; however, in some clones the autosomes from the ES cell partner were also eliminated, i.e. the parental chromosomes segregated bilaterally in the ES-somatic cell hybrids. This opens up ways for searching correlation between the pluripotent status of the hybrid cells and chromosome segregation patterns and therefore... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: ES cells; EG cells; Hybrid cells; Pluripotency; Reprogramming. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652001000400009 |
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