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| SILVA,FERNANDO C.; RODRIGUES,VANESSA G.; DUARTE,LUCIENIR P.; LULA,IVANA S.; SINISTERRA,RUBEN D.; VIEIRA-FILHO,SIDNEY A.; RODRIGUES,RODRIGO A.L.; KROON,ERNA G.; OLIVEIRA,PATRÍCIA L.; FARIAS,LUIZ M.; MAGALHÃES,PAULA P.; SILVA,GRÁCIA D.F.. |
| ABSTRACT Diarrhea is an infectious disease caused by bacterial, virus, or protozoan, and dengue is caused by virus, included among the neglected diseases in several underdeveloped and developing countries, with an urgent demand for new drugs. Considering the antidiarrheal potential of species of Maytenus genus, a phytochemical investigation followed by antibacterial activity test with extracts of branches and heartwood and bark of roots from Maytenus gonoclada were conducted. Moreover, due the frequency of isolation of lupeol from Maytenus genus the antiviral activity against Dengue virus and cytotoxicity of lupeol and its complex with β-cyclodextrins were also tested. The results indicated the bioactivity of ethyl acetate extract from branches and ethanol... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antidiarrheal; Celastraceae; Pentacyclic Triterpene; Antiviral Activity. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401555 |
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| SOARES,DÉBORA B.S.; DUARTE,LUCIENIR P.; CAVALCANTI,ANDRÉ D.; SILVA,FERNANDO C.; BRAGA,ARIADNE D.; LOPES,MIRIAM T.P.; TAKAHASHI,JACQUELINE A.; VIEIRA-FILHO,SIDNEY A.. |
| ABSTRACT The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Psychotria viridis Rubiaceae N; N-dimethyltryptamine B16F10 4T1 tumor cells. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000300927 |
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