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| HERRERA,KARINA M.S.; FERREIRA,LORENA S.; BRAGA,ALYSSON V.; SOUZA,JULIANO P.; ANDRADE,JÉSSICA T.; SOARES,ADRIANA C.; SOARES,LUIS F.; CHAGAS,RAFAEL C.R.; FERREIRA,JAQUELINE M.S.. |
| Abstract: Four novel Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands were synthesized and characterized using elemental, physiochemical, and spectroscopy analytical methods. The results showed the formation of ligands coordinated by sulfur atoms of the C = S bond to the L1 ligand and by the sulfur atom of the C-S bond and/or nitrogen of the intra C-ring bond of the L2 ligand. The activity of the complexes against Gram-negative, Gram-positive bacteria and yeasts of clinical importance was evaluated by broth microdilution method. The best result was obtained to L2-Ni compound against E. cloacae (Minimal Inhibitory Concentration (MIC) = 62.5 µg/mL). Additionally, the compounds showed anti-Candida activity (MIC values... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 1; 2-bis-bis (2-thiazolin-2-isulfanyl) ethane antimicrobial activity hidrotris (2-mercaptothiazolyl) borate complexes. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700803 |
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