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	Provedor de dados OAK (1) Autor Haneda, Masakazu (1) Nakamura, Kimihide (1) Okada, Mitsuyoshi (1) Saito, Ako (1) Yokohama, Shiro (1) Yoneda, Masashi (1) 中村, 公英 (1) Mais... Palavra-chave Concanavalin A (1) Cytokine (1) Fucoidan (1) Kupffer cell (1) Liver injury (1) Scavenger receptor (1) Mais... Ano 2006 (1) País Japan (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Fucoidan prevents concanavalin A-induced liver injury through induction of endogenous IL-10 in mice OAK Saito, Ako; Yoneda, Masashi; Yokohama, Shiro; Okada, Mitsuyoshi; Haneda, Masakazu; Nakamura, Kimihide; 中村, 公英. Fucoidan is a complex of sulfated polysaccharides derived from non-mammalian origin such as marine brown algae and induces cytokine expression. We investigated the effect of fucoidan on concanavalin A (Con A)-induced liver injury in mice. Liver injury was induced by an intravenous injection of Con A (18.5 mg/kg). Various doses of fucoidan (1-30 mg/kg) were intravenously administered 30 min before Con A injection. The plasma alanine aminotransferase (ALT) and several cytokines levels were determined, and hepatic histological changes were also assessed. The effect of fucoidan administration by itself on induction of interleukin (IL)-10 in plasma and liver tissue was investigated. Con A administration induced an elevation of plasma ALT level, and fucoidan... Palavras-chave: Concanavalin A; Fucoidan; Liver injury; Cytokine; Kupffer cell; Scavenger receptor. Ano: 2006 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/66 Registros recuperados: 1 Primeira ... 1 ... Última

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