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| Saleem,Bushra; Islam,Muhammad; Saeed,Hamid; Imtiaz,Fariha; Asghar,Maryam; Saleem,Zikria; Mehmood,Azra; Naheed,Surriya. |
| ABSTRACT The leaves of Acacia modesta Wall. have been shown to possess diverse pharmacological properties. Therefore, we aimed at evaluating anti-diabetic, cytotoxic and proliferative effects of extracts of Acacia modesta Wall. leaves. After evaluating the primary and secondary metabolites, anti-diabetic activity of various extracts was assessed by α-amylase inhibition, glucose uptake by yeast cells and non-enzymatic glycosylation of hemoglobin assay. Cytotoxicity and proliferative potential was assessed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and short term proliferation assays, respectively, using human liver carcinoma cell line, HepG2. Among other extracts, chloroform extract exhibited 34.16% inhibition of α-amylase, 90.65%... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acacia modesta Wall; /anti-diabetic effects/cytotoxic/in vitro; MTT; Phytochemical. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200609 |
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| Saleem,Zikria; Saeed,Hamid; Khan,Zohaib Abbas; Khan,Muhammad Imran Hassan; Hashmi,Furqan Khurshid; Islam,Muhammad; Bashir,Afzaal; Sadeeqa,Saleha. |
| The study was performed to estimate the association of hypertension and dyslipidaemia with increasing body weight and obesity in Type II diabetics of Lahore, Pakistan. An observational study was conducted by enrolling 2708 obese diabetics from four diabetes care centres of Lahore, Pakistan. Data was collected for a period of 7 months. Associations were estimated using chi-square, binary and multinomial logistic regression. Data suggested that blood pressure, systolic and diastolic, exhibited continual increase with increasing body weight and obesity class in diabetes patients with 41.8% increase in the prevalence of hypertension in obesity class III subjects (OR; 1.91, p=0.02). Likewise, triglycerides and total cholesterol exhibited continual increase in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Type II Diabetes Mellitus; Dyslipidaemia; Obesity; HbA1c; Lahore/Pakistan. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100503 |
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