Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BJMBR (4) Autor Sampaio,E.P. (4) Sarno,E.N. (4) Alvarenga,F.F. (1) Antas,P.R.Z. (1) Azevedo,L.M.S. (1) Cunha,K.S. (1) Duppre,N.C. (1) Ferreira,H. (1) Galhardo,M.C.G. (1) Matos,H.J.de (1) Morgado,M.G. (1) Nery,J.A.C. (1) Oliveira,E.B. (1) Pereira,K.C. (1) Perez,M. (1) Sales,A.M. (1) Sales,J.S. (1) Schueler,G. (1) Mais... Palavra-chave Leprosy (2) Anti-hCD28 mAb (1) CD4-CD8 ratio (1) CD8 T cells (1) Cytokines (1) Eprosy (1) HIV (1) IFN-gamma (1) Langerhans cells (1) Pentoxifylline (1) Reactional episodes (1) Reactions (1) Skin immune system (1) TNF-alpha (1) Thalidomide (1) Therapy (1) Tuberculosis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Info:eu-repo/semantics/other (1) Ano 2007 (1) 2004 (2) 1998 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Double-blind trial of the efficacy of pentoxifylline vs thalidomide for the treatment of type II reaction in leprosy BJMBR Sales,A.M.; Matos,H.J.de; Nery,J.A.C.; Duppre,N.C.; Sampaio,E.P.; Sarno,E.N.. Type II reaction in leprosy, or erythema nodosum leprosum (ENL), is often characterized by severe clinical symptoms together with nerve function impairment leading to permanent disabilities. Thalidomide has been shown to be a highly effective drug for the treatment of ENL. It is, however, contraindicated for women of childbearing age due to its teratogenicity. On the other hand, pentoxifylline, used to treat hypercoagulable states, is not teratogenic and, like thalidomide, can inhibit the synthesis of tumor necrosis factor-a and other cytokines. In the present randomized double-blind clinical study we compared the effectiveness of orally administered pentoxifylline vs thalidomide in treating type II reaction in 44 patients. Daily doses of 300 mg... Tipo: Info:eu-repo/semantics/other Palavras-chave: Leprosy; Reactional episodes; Therapy; Pentoxifylline; Thalidomide. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000200011 Normal skin of HIV-infected individuals contains increased numbers of dermal CD8 T cells and normal numbers of Langerhans cells BJMBR Galhardo,M.C.G.; Alvarenga,F.F.; Schueler,G.; Perez,M.; Morgado,M.G.; Ferreira,H.; Azevedo,L.M.S.; Sampaio,E.P.; Sarno,E.N.. Dysregulation of the skin immune system (SIS) could explain the high prevalence of skin disorders in HIV+ individuals. The present study was carried out to determine whether alterations in the cell population of SIS and epidermal immunoactivation occur in the normal skin of HIV+ individuals. Forty-five biopsies were taken from the normal upper arm skin of 45 HIV+ patients and of 15 healthy controls. HIV+ individuals were divided into three categories according to their CD4 cell blood count (<200, 200-499 and ³500/µl). Hematoxylin-eosin was used to stain tissue sections for morphological analysis and immunohistochemistry was used for the evaluation of the frequency of macrophages, Langerhans cells, and CD lymphocyte subsets. In addition, semiquantitative... Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; Skin immune system; CD8 T cells; CD4-CD8 ratio; Langerhans cells. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000500017 Expression and cytokine secretion in the states of immune reactivation in leprosy BJMBR Sampaio,E.P.; Sarno,E.N.. Leprosy is a chronic inflammatory disease caused by Mycobacterium leprae. The human response to this pathogen exhibits intriguing aspects which are up to now not well understood. The present study discusses the probable mechanisms involved in T cell-specific unresponsiveness observed in lepromatous patients. Analysis of the cytokine profile either in blood leukocytes or in skin specimens taken from leprosy lesions indicates that some parameters of Th1 immune response are present in lepromatous patients under reactional states Tipo: Info:eu-repo/semantics/article Palavras-chave: Eprosy; Reactions; Cytokines. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100009 Patterns of intracellular cytokines in CD4 and CD8 T cells from patients with mycobacterial infections BJMBR Antas,P.R.Z.; Sales,J.S.; Pereira,K.C.; Oliveira,E.B.; Cunha,K.S.; Sarno,E.N.; Sampaio,E.P.. Using a short-term bulk culture protocol designed for an intracellular-staining method based on a flow cytometry approach to the frequencies of cytokine-producing cells from tuberculosis and leprosy patients, we found distinct patterns of T cell subset expression. The method also reveals the profile of peak cytokine production and can provide simultaneous information about the phenotype of cytokine-producing cells, providing a reliable assay for monitoring the immunity of these patients. The immune response of Mycobacterium leprae and purified protein derivative (PPD) in vitro to a panel of mycobacteria-infected patients from an endemic area was assessed in primary mononuclear cell cultures. The kinetics and source of the cytokine pattern were measured at... Tipo: Info:eu-repo/semantics/article Palavras-chave: Tuberculosis; Leprosy; IFN-gamma; TNF-alpha; Anti-hCD28 mAb. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000800003 Registros recuperados: 4 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco