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	Provedor de dados J. Venom. Anim. Toxins incl. Trop. Dis. (2) Autor Sampaio,R. N. R. (2) Friedman,H. (1) Lucas,I. C. (1) Paula,C. D. R. (1) Takami,H. L. (1) Palavra-chave American leishmaniasis (1) Animal model (1) Cavia (1) Cutaneous Leishmaniasis (1) Experimental leishmaniasis (1) Miltefosine (1) N-methyl glucamine (1) Pathogenesis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2007 (1) 2005 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Use of Cavia porcellus (guinea pigs) as an experimental model for Leishmania (Viannia) braziliensis J. Venom. Anim. Toxins incl. Trop. Dis. Paula,C. D. R.; Friedman,H.; Sampaio,R. N. R.. Laboratory animals are fundamental to study immunological aspects and the efficacy of new drugs to treat leishmaniasis. However, we do not have practical and good animal models to study leishmaniasis caused by Leishmania (Viannia) braziliensis - L(V)b. In this study, thirty-two experimental animals (Cavia porcellus) were injected in the hind foot with 3x10(5) promastigote forms of L(V)b. The animals were followed for eight weeks. None of the experimental animals developed lesions or presented the parasite in any of the tests performed (histopathological exam, smears, culture, inoculation in hamsters, and polymerase chain reaction). Tipo: Info:eu-repo/semantics/article Palavras-chave: Experimental leishmaniasis; Cavia; Animal model; American leishmaniasis; Pathogenesis. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000400017 Inefficacy of the association N-methyl glucamine and topical miltefosine in the treatment of experimental cutaneous leishmaniasis by Leishmania (Leishmania) amazonensis J. Venom. Anim. Toxins incl. Trop. Dis. Sampaio,R. N. R.; Lucas,I. C.; Takami,H. L.. Pentavalent antimonial (SbV) is the first treatment for cutaneous leishmaniasis (CL). Other drugs present similar side effects and higher cost. Oral miltefosine is effective to treat kala-azar. The aim of the present study was to compare the efficacy of glucamine (SbV) plus topical miltefosine with glucamine in the treatment of CL. Eighty isogenic C57BL/6 mice were inoculated with Leishmania (Leishmania) amazonensis and divided into two groups: one group was treated with SbV associated with miltefosine, and the other group received SbV plus saline solution. Groups were evaluated according to the diameter of the inoculated foot pad, the culture, and the parasite count using the limiting dilution assay. There was not statistical difference. The efficacy of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cutaneous Leishmaniasis; Miltefosine; N-methyl glucamine. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000300004 Registros recuperados: 2 Primeira ... 1 ... Última

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