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| Otobone,Fernanda Jacques; Sanches,Andréia Conegero; Nagae,Rosangela Lika; Martins,Juliana Vanessa Colombo; Obici,Simoni; Mello,João Carlos Palazzo de; Audi,Elisabeth Aparecida. |
| The effect of crude lyophilized extract (EBPC) and the semi-purified constituents (EPA and EPB) of Paullinia cupana (guaraná) seeds long-term administered in rats by gavage at different doses was studied on cognitive behavior in rats. EBPC (30.0 mg/kg) and EPA (2.0 mg/kg), but not EPB (2.0 or 4.0 mg/kg) showed a smaller escape latency to find the emerged platform in Morris water maze test (MWMT), showing nootropic-like effect in normal rats, and in scopolamine induced amnesia rats compared to their controls (saline + 0.2% Tween 80) group. These extracts had no significant effect in open field test (OFT). Caffeine did alter escape latency in MWMT only in scopolamine induced amnesia rats and increased the crossings number in OFT, showing significant... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cognitive effects; Guaraná; Morris water maze; Paullinia cupana. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000600007 |
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