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| Cavalcanti,Noely Camila Tavares; Sousa,Giovana Damasceno; Tabosa,Maria Alice Maciel; Soares Sobrinho,José Lamartine; Leal,Leila Bastos; Santana,Davi Pereira de. |
| The aim of this study was to characterize three batches of albendazole by pharmacopeial and complementary analytical techniques in order to establish more detailed specifications for the development of pharmaceutical forms. The ABZ01, ABZ02, and ABZ03 batches had melting points of 208 ºC, 208 ºC, and 209 ºC, respectively. X-ray diffraction revealed that all three batches showed crystalline behavior and the absence of polymorphism. Scanning electron microscopy showed that all the samples were crystals of different sizes with a strong tendency to aggregate. The samples were insoluble in water (5.07, 4.27, and 4.52 mg mL-1, respectively) and very slightly soluble in 0.1 M HCl (55.10, 56.90, and 61.70 mg mL-1, respectively) and additionally showed purities... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Albendazole/characterization; Antiparasitics/quality control. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000200012 |
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| Velloso,Fabiana Toledo; Ferraz,Rafaela Siqueira; Lira,Ana Amélia Moreira; Santana,Davi Pereira de; Santos-Magalhães,Nereide Stela. |
| O ácido retinóico (AR) tem sido utilizado para o tratamento de acne severa, rugas, estrias e celulite, no entanto, provoca irritação na pele e sofre rápida degradação quando exposto à luz e ao calor. Métodos analíticos rápidos para quantificação do AR são, portanto, necessários para ensaios de cinética de liberação in vitro. Nesse contexto, o objetivo deste trabalho foi desenvolver e validar um método rápido e sensível para o doseamento do AR em microcápsulas de alginato/quitosana contendo óleo de babaçu dispersas em gel natrosol® por cromatografia líquida de alta eficiência associada à espectroscopia UV e aplicá-lo na avaliação do perfil de liberação in vitro dessas formulações. As análises foram realizadas em modo isocrático utilizando coluna C18 de fase... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cromatografia líquida de alta eficiência; Espectroscopia/ultra violeta; Ácido retinóico/quantificação; Microcápsulas/análise quantitativa; Formulações farmacêuticas/liberação in vitro. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000100022 |
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| Melo,Elayne Karine Souto de; Araujo,Thalita Pedon de; Silva,José Wellithom Viturino da; Chagas,Stephanye Carolyne Christino; Bedor,Danilo César Galindo; Santana,Davi Pereira de; Leal,Leila Bastos. |
| ABSTRACT Metronidazole (MTZ) is widely used as the standard antibiotic for the treatment of rosacea and, more recently, is being used off label in Brazilian hospitals for the treatment of wounds. Following oral administration, minimal amounts of active agent reaches the skin and side effects are strongly induced. Consequently, MTZ is currently being applied topically in order to improve the therapeutic efficacy with reduced side effects, with Rozex(r) (RZ) (an MTZ gelled formulation) being the only marketed product. This study examined whether the use of MTZ 0.75% from thermogel formulations could improve drug retention and reduce dermal exposure compared to that by Rozex(r). Following a 21 h permeation study, the highest total amount of MTZ permeated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Metronidazole/evaluation; Metronidazole/drug retention; Poloxamer 407; Rosacea/treatment; Dermatopharmacokinetic.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200626 |
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| Leal,Leila Bastos; Sousa,Giovana Damasceno; Seixas,Karoline Belém; Souza,Pedro Henrique Nogueira de; Santana,Davi Pereira de. |
| The aims of this study were to determine the critical hydrophile-lipophile balance (HLB) of licuri oil, and to perform a clinical assay to evaluate its hydrating effects. For the determination of the HLB, serial emulsions were prepared with the oil. Regarding the clinical study, 13 human subjects were recruited to evaluate the hydrating power of the emulsified preparation containing licuri oil, and comparing it with the same preparation containing sweet almond oil (SAO). The critical HLB of licuri oil was represented by the zones within the concentrations of 10% for the oil and 15% for the pair of tensoactive agents, with a value of 11.8. Both preparations showed similar hydrating power. We propose that licuri oil can be considered a new lipophilic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Licuri/fixed oil; Licuri/determination of hydrophile-lipophile balance; Licuri/fixed oil; Licuri/hydration effects; Emulsions/preparation with licuri oil; Skin hydration. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100018 |
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