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Infection of Caenorhabditis elegans by Salmonella typhi Ty2 Electron. J. Biotechnol.
Santander,Javier; Espinoza,Juan Carlos; Campano,María Soledad; Robeson,James.
Several serovars of Salmonella infect and kill the nematode C. elegans. However, here we report that Salmonella typhi Ty2, a representative strain of this human pathogen, readily infects the intestinal lining of C. elegans without significantly affecting its viability. Our observation suggests extending the use of the C. elegans model system for the study of host parasite relationships, to address problems concerning the biology of S. typhi.
Tipo: Journal article
Ano: 2003 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582003000200008
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Bacteriophage prophylaxis against Salmonella enteritidis and Salmonella pullorum using Caenorhabditis elegans as an assay system Electron. J. Biotechnol.
Santander,Javier; Robeson,James.
Tipo: Journal article
Ano: 2004 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582004000200012
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Phage-resistance of Salmonella enterica serovar Enteritidis and pathogenesis in Caenorhabditis elegans is mediated by the lipopolysaccharide Electron. J. Biotechnol.
Santander,Javier; Robeson,James.
Phage therapy has been used in the past as an alternative therapy against bacterial pathogens. However, phage-resistant bacterial strains can emerge. Some studies show that these phage-resistant strains are avirulent. In this study, we report that phage-resistant strains of Salmonella enterica serovar Enteritidis (hereafter S. Enteritidis) were avirulent in the Caenorhabditis elegans animal model. We isolated phage-resistant strains of S. Enteritidis ATCC 13076 by using three lytic phages (f2αSE, f3αSE and f18αSE). In these mutants, we explored different virulence factors like lipopolysaccharide (LPS), virulence plasmid (Pla), motility and type I fimbriae, all of which may have effects on virulence and could furthermore be...
Tipo: Journal article Palavras-chave: Animal model; Bacteriophage prophylaxis; Caenorhabditis elegans; Phage resistance; Salmonella.
Ano: 2007 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582007000400015
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