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Non-random distribution of high density chromatin detected at opposite ends of T-banded human metaphase chromosomes Genet. Mol. Biol.
Santiñaque,Federico F.; Drets,Máximo E..
Previous research using microdensitometric scanning and computer graphic image analysis showed that T-banded segments of human metaphase chromosomes usually exhibit an asymmetrical distribution of high density (HD) chromatin between sister chromatids. Here, we employed the same methods to analyze HD chromatin distribution at opposite ends of T-banded human lymphocyte chromosomes. This study revealed that in most chromosomes with an asymmetrical distribution of HD chromatin at both ends, the highest densities of each arm were located in opposite chromatids. The frequency of this configuration was 0.792 per chromosome, indicating that the highest chromatin densities of the terminal segments of T-banded human chromosomes were non-randomly distributed at...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Human chromosomes; T-banding; Chromatin structure; Telomere; Microdensitometry.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000600004
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A proposal of a standardised nomenclature for terminal minute sister chromatid exchanges Genet. Mol. Biol.
Drets,Máximo E.; Santiñaque,Federico F.; Obe,Günter.
We described spontaneous minute sister chromatid exchanges (SCE) in telomeric regions of human and Chinese hamster ovary (CHO) chromosomes more than 10 years ago. These structures, which we called t-SCE, were detected by means of highly precise quantitative microphotometrical scanning and computer graphic image analysis. Recently, several authors using the CO-FISH method also found small SCEs in telomeric regions and called them T-SCE. The use of different terms for designating the same phenomenon should be avoided. We propose ter SCE as a uniform nomenclature for minute telomeric SCEs.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Minute telomeric SCEs; Chromosome nomenclature.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000300007
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