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| Santos,Karolina Torres; Silva,Fabricio Ocampo da Luz e; Schneider,Leandro Alves; Santos,Carlos Eduardo Rangel dos; Silva,Sue Elle Berro da; Fernandes,Maquelen Blanco; Rocha,Leandro; Oliveira,Luís Flávio Souza de; Machado,Michel Mansur; Moreira,Cleci Menezes. |
| The essential oil of the leaves of Eugenia sulcata, in the Myrtaceae family, has a demonstrated antihypertensive effect, but its effects on heart muscle and its toxicity have not yet been elucidated. Little chemical or biological data are available for E. sulcata, whether emphasizing the beneficial effects or the pharmacological security of this species. This study aims to evaluate myocardial contractility and to analyze angiotensin converting enzyme (ACE) and myosin ATPase activities associated with use of this essential oil. In addition, we evaluated the immunotoxicity of E. sulcata essential oil. Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) were treated daily for 30 days (10 mg/kg of oil) to evaluate the isometric force of the papillary... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Myrtaceae/adverse effects; Angiotensin-Converting Enzyme Inhibitors/immunology. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100532 |
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