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Measurement of peripheral blood mononuclear cells producing IFN-Gamma in patients with tuberculosis BJID
Andrade Júnior,Dahir Ramos de; Santos,Sânia Alves dos; Andrade,Dahir Ramos de.
The type of immune response induced by tuberculosis (Th1 or Th2) and its correlation with the clinical outcome is unclear. We studied 13 patients with active tuberculosis (TBC). The peripheral blood mononuclear cells producing IFN-gamma (PBMC-IG) were measured by enzyme-linked immunospot (ELISPOT) technique. The control group had ten healthy individuals vaccinated against tuberculosis. We collected blood samples of each patient in two moments: a) in the hospital admission without treatment (TBC1); b) after seven to 20 days of treatment (TBC2). The comparison of the spots forming units of PBMC-IG between TBC group and controls showed that there was a significant difference between TBC1 and control group (p < 0.001) and between TBC2 and control group (p...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tuberculosis; Th1 immune response; ELISPOT.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200005
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Correlation between serum tumor necrosis factor alpha levels and clinical severity of tuberculosis BJID
Andrade Júnior,Dahir Ramos de; Santos,Sânia Alves dos; Castro,Isac de; Andrade,Dahir Ramos de.
This study verified the correlation between the serum levels of TNF alpha and different clinical forms of tuberculosis. We described a group of 24 patients presenting several clinical forms of tuberculosis and a control group of 13 healthy individuals. The levels of TNF alpha were measured by bioassay method. The levels of TNF-alpha had significant differences between the tuberculosis and control groups. The patients with abnormal chest X-Ray findings had higher TNF alpha levels (15328.48 ± 4602.19 pg/mL) when compared to patients with normal X-Rays (3353.18 ± 1495.29 pg/mL) (p<0.05). Patients that lost weight had higher TNF alpha levels (15468.54 ± 4580.54 pg/mL) than those that didn't loose weight (2904.98 ± 1367.89) (p<0.05). The levels of TNF...
Tipo: Info:eu-repo/semantics/article Palavras-chave: TNF alpha; Tuberculosis; Cytokines; Clinical severity.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300013
Registros recuperados: 2
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