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| Gusmão,Karla A. G.; Santos,Daniel M. dos; Santos,Virgílio M.; Cortés,María Esperanza; Reis,Pablo V. M.; Santos,Vera L.; Piló-Veloso,Dorila; Verly,Rodrigo M.; Lima,Maria Elena de; Resende,Jarbas M.. |
| Abstract Background The availability of antimicrobial peptides from several different natural sources has opened an avenue for the discovery of new biologically active molecules. To the best of our knowledge, only two peptides isolated from the frog Leptodactylus labyrinthicus, namely pentadactylin and ocellatin-F1, have shown antimicrobial activities. Therefore, in order to explore the antimicrobial potential of this species, we have investigated the biological activities and membrane interactions of three peptides isolated from the anuran skin secretion. Methods Three peptide primary structures were determined by automated Edman degradation. These sequences were prepared by solid-phase synthesis and submitted to activity assays against gram-positive... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leptodactylus labyrinthicus; Ocellatins; Antimicrobial peptides; Peptide membrane interactions. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100302 |
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