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Chronic intermittent exposure to ayahuasca during aging does not affect memory in mice BJMBR
Correa-Netto,N.F.; Coelho,L.S.; Galfano,G.S.; Nishide,F.; Tamura,F.; Shimizu,M.K.; Santos Junior,J.G.; Linardi,A..
The Quechua term ayahuasca refers to a beverage obtained from decoctions of the liana Banisteriopsis caapi with leaves of Psychotria viridis. The ritualistic use of ayahuasca is becoming a global phenomenon, with some individuals using this beverage throughout life, including in old age. Cognitive impairment is a common manifestation during aging. There are conflicting reports on the ability of some ayahuasca compounds to exert neuroprotective or neurotoxic effects that could improve or impair learning and memory. Animal models provide a relevant and accessible means of investigating the behavioral effects of ayahuasca without the environmental conditions associated with the ritualistic use of the beverage. In this study, we investigated the influence of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Anxiety Banisteriopsis Carbolines N; N-dimethyltryptamine Learning.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000700604
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An ontogenic study of the behavioral effects of chronic intermittent exposure to ayahuasca in mice BJMBR
Correa-Netto,N.F.; Masukawa,M.Y.; Nishide,F.; Galfano,G.S.; Tamura,F.; Shimizo,M.K.; Marcato,M.P.; Santos Junior,J.G.; Linardi,A..
Ayahuasca is a beverage obtained from decoctions of the Banisteriopsis caapi plus Psychotria viridis. In religious contexts, ayahuasca is used by different age groups. However, little is known of the effects of ayahuasca during ontogenic development, particularly with regard to the functional characteristics of the central nervous system. Animal models are useful for studying the ontogenic effects of ayahuasca because they allow exclusion of the behavioral influence associated with the ritualistic use. We investigated the effects of exposure to ayahuasca (1.5 mL/kg, orally, twice a week) on memory and anxiety in C57BL/6 mice, with the post-natal day (PND) being used as the ontogenic criterion for classification: childhood (PND21 to PND35), adolescence...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Adolescent Anxiety Banisteriopsis N; N-Dimethyltryptamine Infant Memory.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000700603
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Proconvulsant effects of high doses of venlafaxine in pentylenetetrazole-convulsive rats BJMBR
Santos Junior,J.G.; Do Monte,F.H.M.; Russi,M.; Agustine,P.E.; Lanziotti,V.M.N.B..
Venlafaxine, an atypical antidepressant drug, has been used to treat several neurological disorders, presenting excellent efficacy and tolerability. Clinical seizures after venlafaxine treatment have occasionally been reported when the drug was used at very high doses or in combination with other medications. The aim of the present study was to investigate the convulsant effects of venlafaxine in rats under controlled laboratory conditions. Adult male Wistar rats (8 per group) receiving venlafaxine or saline at the doses of 25-150 mg/kg were subjected 30 min later to injections of pentylenetetrazole at the dose of 60 mg/kg. The animals receiving 75, 100 and 150 mg/kg venlafaxine presented increased severity of convulsion when compared to controls (P =...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Antidepressant; Venlafaxine; Convulsion; Epilepsy; Pentylenetetrazole.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000400010
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