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	Provedor de dados J. Venom. Anim. Toxins incl. Trop. Dis. (4) BJMBR (1) Autor Sartori,A. (5) Bastos,M. F. (2) Ferreira,J. (2) Peres,C. M. (2) Albas,A. (1) Bannwart,C.F. (1) Bonato,V.L.D. (1) Bremer Neto,H. (1) Cavalcante,D. P. (1) Fonseca,D.M. (1) Fontolan,O. L. (1) Nakaira,E.T. (1) Pardo,P. E. (1) Pelizon,A. C. (1) Peraçoli,M.T.S. (1) Silva,C.L. (1) Mais... Palavra-chave Antibody (1) Atherosclerosis (1) Bothrops jararaca (1) Bothrops jararaca venom (1) Cattle (1) Cholesterol (1) DNA-HSP65 (1) ELISA (1) Edema (1) Enzyme-linked immunosorbent assay (1) Genetic vaccine (1) Innate immunity (1) Interleukin-15 (1) Microbial infections (1) Neutralization (1) Ovine anti-bothropic serum (1) Ovine antiserum (1) Rabies (1) Th1 (1) Tuberculosis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (5) Ano 2007 (2) 2006 (2) 2005 (1) País Brazil (5) Idioma Inglês (5)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 5 Primeira ... 1 ... Última Detection and neutralization of venom by ovine antiserum in experimental envenoming by Bothrops jararaca J. Venom. Anim. Toxins incl. Trop. Dis. Peres,C. M.; Bastos,M. F.; Ferreira,J.; Sartori,A.. In this study we optimized an enzyme-linked immunosorbent assay (ELISA) to evaluate bothropic venom levels in biological samples. These samples were obtained by two distinct protocols. In the first one, Swiss mice were injected with 1 LD50 of Bothrops jararaca (B. jararaca) venom and 15 minutes later, animals were treated with ovine antibothropic serum. Blood and spleen homogenate samples were obtained 6 hours after antiserum therapy. Ovine antibothropic serum significantly neutralized venom levels in serum and spleen. In the second protocol, BALB/c mice were injected with 1 LD50 of bothropic venom by either intraperitoneal (IP) or intradermal (ID) route and venom levels were evaluated 1, 3 and 6 hours after, in blood, spleen homogenates and urine. Serum... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bothrops jararaca; Enzyme-linked immunosorbent assay; Ovine anti-bothropic serum; Venom neutralization. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000100010 Assessment of the neutralizing potency of ovine antivenom in a swiss mice model of Bothrops jararaca envenoming J. Venom. Anim. Toxins incl. Trop. Dis. Ferreira,J.; Bastos,M. F.; Pelizon,A. C.; Peres,C. M.; Cavalcante,D. P.; Sartori,A.. Alternative sources of anti-ophidic serum are being investigated due to the secondary effects associated with types I and II hypersensitivity reactions. In the present study we raised and evaluated the protective effect of an ovine antibothropic serum in a Swiss mice envenoming model. Ovine antiserum was obtained by immunization with seven increasing doses of bothropic venom associated with adjuvants. The neutralizing ability was tested by the lethal activity (2 LD50) neutralization and serum and splenic venom levels after antivenom administration to experimentally envenomed mice. The antiserum effect on local edema was also tested by injection of venom/antivenom mixtures into the mice footpads. Ovine antiserum neutralized lethal activity and also... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bothrops jararaca venom; Ovine antiserum; Venom levels; Edema; ELISA. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000300010 Interleukin-15: its role in microbial infections J. Venom. Anim. Toxins incl. Trop. Dis. Bannwart,C.F.; Nakaira,E.T.; Sartori,A.; Peraçoli,M.T.S.. Interleukin-15 (IL-15) is a pleiotropic cytokine which regulates the proliferation, survival and the secretory activities of many distinct cell types in the body. This cytokine is produced by macrophages and many other cell types in response to infectious agents; it controls growth and differentiation of T and B lymphocytes, activation of Natural Killer (NK) and phagocytic cells, and contributes to the homeostasis of the immune system. The present review focuses on the biological and modulatory effects of IL-15 in microbial infections and shows that this cytokine may play a role in the host defense against infections by inducing activation of effector cells from both innate and adaptive immune system. Tipo: Info:eu-repo/semantics/article Palavras-chave: Interleukin-15; Microbial infections; Innate immunity. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000300002 Interval between first dose and booster affected antibody production in cattle vaccinated against rabies J. Venom. Anim. Toxins incl. Trop. Dis. Albas,A.; Fontolan,O. L.; Pardo,P. E.; Bremer Neto,H.; Sartori,A.. In this study, we compared the levels of neutralizing antibodies induced by inactivated rabies vaccine in cattle by using three alternative immunization procedures. Forty-five bovines (breed nelore) were then organized in three groups (A, B and C, with 15 animals/group). Group A received only one vaccine dose at day zero and Group B received the first dose at day zero and then another dose at day 30 (early booster). Group C was also immunized with two doses; however, the booster was postponed until day 180 after the first dose (delayed booster). Blood samples were withdrawn at days zero (before the first dose) and 30, 210, 390, and 540 after the beginning of immunization and the antibody titers were evaluated by mouse neutralization test. The protocol used... Tipo: Info:eu-repo/semantics/article Palavras-chave: Rabies; Vaccine; Cattle; Antibody; Neutralization. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000300010 Th1 polarized response induced by intramuscular DNA-HSP65 immunization is preserved in experimental atherosclerosis BJMBR Fonseca,D.M.; Bonato,V.L.D.; Silva,C.L.; Sartori,A.. We previously reported that a DNA vaccine constructed with the heat shock protein (HSP65) gene from Mycobacterium leprae (DNA-HSP65) was protective and also therapeutic in experimental tuberculosis. By the intramuscular route, this vaccine elicited a predominant Th1 response that was consistent with its protective efficacy against tuberculosis. It has been suggested that the immune response to Hsp60/65 may be the link between exposure to microorganisms and increased cardiovascular risk. Additionally, the high cholesterol levels found in atherosclerosis could modulate host immunity. In this context, we evaluated if an atherogenic diet could modulate the immune response induced by the DNA-HSP65 vaccine. C57BL/6 mice (4-6 animals per group) were initially... Tipo: Info:eu-repo/semantics/article Palavras-chave: DNA-HSP65; Genetic vaccine; Atherosclerosis; Tuberculosis; Th1; Cholesterol. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100010 Registros recuperados: 5 Primeira ... 1 ... Última

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