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Evaluation of immunomodulatory effects of lomefloxacin in mice BJPS
Majeed,Arfa; Javeed,Aqeel; Omer,Muhammad Ovais; Mushtaq,Muhammad Hassan; Sattar,Adeel.
Lomefloxacin is a flouroquinolone antibiotic that is quite efficacious against many gram negative and gram positive pathogens. Lomefloxacin evince antibacterial effects by modifying DNA gyrase in gram negative pathogens and topoisomerase IV in gram positive pathogens. This study is designed to assess the immunomodulatory effects of lomefloxacin in male albino mice. Three doses of lomefloxacin 12.5 mg/kg, 25 mg/kg and 50 mg/kg were used and delayed type hypersensitivity assay, cyclophosphamide induced neutropenic assay, carbon clearance assay, heamagglutination assay and mice lethality test were performed to evaluate the effects of lomefloxacin on immune system of mice. DTH assay has depicted the significant immunosuppressant potential of lomefloxacin at 25...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cell-mediated; Humoral; Immunomodulatory; Immune response; Lomefloxacin.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100628
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