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| Vecchia,Débora Dalla; Schamne,Marissa Giovanna; Ferro,Marcelo Machado; Santos,Ana Flávia Chaves dos; Latyki,Camila Lupepsa; Lara,Danilo Vieira de; Ben,Juliana; Moreira,Eduardo Luiz; Prediger,Rui Daniel; Miyoshi,Edmar. |
| Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by the slow and progressive death of dopaminergic neurons in the (substantia nigra pars compact). Hypericum perforatum (H. perforatum) is a plant widely used as an antidepressant, that also presents antioxidant and anti-inflammatory properties. We evaluated the effects of H. perforatum on the turning behavior of rats submitted to a unilateral administration of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle as an animal model of PD. The animals were treated with H. perforatum (100, 200, or 400 mg/kg, v.o.) for 35 consecutive days (from the 28th day before surgery to the 7th day after). The turning behavior was evaluated at 7, 14 and 21 days after the surgery,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Parkinson's disease/treatment/experimental study; H. perforatum/phytotherapy/neuroprotective effect; Turning behavior; 6-OHDA. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100111 |
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