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	Provedor de dados Genet. Mol. Biol. (2) Autor Schiengold,Marion (2) Cazarolli,Juciana (1) Chies,Jose Artur Bogo (1) Chies,José Artur Bogo (1) Gonzalez,Tatiana P. (1) Lothhammer,Nívia (1) Nardi,Nance B. (1) Ribeiro,Maria F. (1) Salzano,Francisco Mauro (1) Schwantes,Lavínia (1) Veit,Tiago Degani (1) Mais... Palavra-chave Adrenal gland (1) Amerindians (1) Balancing selection (1) HLA-G 14 bp INDEL (1) Multidrug resistance (1) Ovaries (1) Pathogen resistance (1) Steroids (1) Uterus (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2012 (1) 2006 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última New evidence for balancing selection at the HLA-G locus in South Amerindians Genet. Mol. Biol. Veit,Tiago Degani; Cazarolli,Juciana; Salzano,Francisco Mauro; Schiengold,Marion; Chies,José Artur Bogo. HLA-G is a non-classical HLA (Human Leukocyte Antigen) molecule characterized by limited tissue distribution under normal physiological conditions and low variability at both DNA and protein levels. Several studies suggest that HLA-G could play a role, as an immunoregulatory molecule, in situations as diverse as transplantation, cancer, viral infections and inflammatory diseases. A total of 237 individuals from 21 South American tribes speaking nine different linguistic families were studied in relation to the 14 bp insertion/deletion polymorphism at the HLA-G gene. A consistent (seven in nine) excess of heterozygosity in samples classified by language was obtained. Our data supply evidences for balancing selection acting at the HLA-G 14 bp INDEL region.... Tipo: Info:eu-repo/semantics/article Palavras-chave: HLA-G 14 bp INDEL; Balancing selection; Amerindians; Pathogen resistance. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000600005 Expression of mdr isoforms in mice during estrous cycle and under hormone stimulation Genet. Mol. Biol. Schiengold,Marion; Schwantes,Lavínia; Ribeiro,Maria F.; Lothhammer,Nívia; Gonzalez,Tatiana P.; Chies,Jose Artur Bogo; Nardi,Nance B.. The multidrug resistance (MDR) phenotype is associated with the expression of P-glycoprotein (Pgp), coded by the multigenic mdr family. Mice present the isoforms mdr1 and mdr3, which are responsible for multidrug resistance, and mdr2, that is involved in the transport of phospholipids. mdr1 expression has more recently been associated also with the secretion of steroid hormones. This work presents an RT-PCR analysis of the expression of mdr isoforms, in several organs of mice during different phases of the estrous cycle. Additionally, females were ovariectomized, submitted to different hormone treatments, and their uterus was analyzed for the expression of mdr isoforms. The results show that in the adrenal gland and ovaries mdr1 is the main isoform during... Tipo: Info:eu-repo/semantics/article Palavras-chave: Adrenal gland; Multidrug resistance; Ovaries; Steroids; Uterus. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000400029 Registros recuperados: 2 Primeira ... 1 ... Última

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