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Cardioprotective effect of ornitho-kinin in an anesthetized, open-chest chicken model of acute coronary occlusion BJMBR
Prezoto,B.C.; Couto,G.K.; Rossoni,L.V.; Schoorlemmer,G.H.M.; Carillo,B.A.; Campos,R.R..
The generation of bradykinin (BK; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) in blood and kallidin (Lys-BK) in tissues by the action of the kallikrein-kinin system has received little attention in non-mammalian vertebrates. In mammals, kallidin can be generated by the coronary endothelium and myocytes in response to ischemia, mediating cardioprotective events. The plasma of birds lacks two key components of the kallikrein-kinin system: the low molecular weight kininogen and a prekallikrein activator analogous to mammalian factor XII, but treatment with bovine plasma kallikrein generates ornitho-kinin [Thr6,Leu8]-BK. The possible cardioprotective effect of ornitho-kinin infusion was investigated in an anesthetized, open-chest chicken model of acute coronary...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chicken; Infarct size; Kallikrein-kinin system; Ornitho-kinin; Factor XII.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000900009
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Changes in sodium appetite evoked by lesions of the commissural nucleus of the tractus solitarius BJMBR
Ogihara,C.A.; Schoorlemmer,G.H.M.; Colombari,E.; Sato,M.A..
Ablation of the area postrema/caudal nucleus of the tractus solitarius (NTS) complex increases sodium intake, but the effect of selective lesions of the caudal NTS is not known. We measured depletion-induced sodium intake in rats with electrolytic lesions of the commissural NTS that spared the area postrema. One day after the lesion, rats were depleted of sodium with furosemide (10 mg/kg body weight, sc) and then had access to water and a sodium-deficient diet for 24 h when 1.8% NaCl was offered. Water and saline intakes were measured for 2 h. Saline intake was higher in lesioned than in sham-lesioned rats (mean ± SEM: 20 ± 2 vs 11 ± 3 mL/2 h, P < 0.05, N = 6-7). Saline intake remained elevated in lesioned rats when the tests were repeated 6 and 14 days...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nucleus of the solitary tract; Sodium appetite; Sucrose; Furosemide.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600014
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