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	Provedor de dados J. Venom. Anim. Toxins incl. Trop. Dis. (2) Autor Pimenta,Daniel C. (2) Sciani,Juliana M. (2) Bueno,Thais C. (1) Cavalcante,Ingrid (1) Chagas,Bruno B. (1) Collaço,Rita C. O. (1) Fucase,Tamara M. (1) Lavezo,Aline A. (1) Pereira,Patricia M. C. (1) Rocha,Thalita (1) Silva,Andrea C. R. (1) Spencer,Patrick J. (1) Viala,Vincent L. (1) Vigerelli,Hugo (1) Mais... Palavra-chave Bufotenine (1) Hypotension (1) Peptide (1) Rabies (1) Rabies therapy (1) Viperinae (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2017 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Bufotenine, a tryptophan-derived alkaloid, suppresses the symptoms and increases the survival rate of rabies-infected mice: the development of a pharmacological approach for rabies treatment J. Venom. Anim. Toxins incl. Trop. Dis. Vigerelli,Hugo; Sciani,Juliana M.; Pereira,Patricia M. C.; Lavezo,Aline A.; Silva,Andrea C. R.; Collaço,Rita C. O.; Rocha,Thalita; Bueno,Thais C.; Pimenta,Daniel C.. Abstract Background: Between 40,000-70,000 people die yearly of rabies, an incurable disease. Besides post-bite vaccination, no treatment is available for it. Methods: First, virus dilution for antiviral effects in mice was determined. Then, animals were treated as follows: control (NaCl 250 µL/animal/day); bufotenine (0.63, 1.05 and 2.1 mg in 250 µL of NaCl/animal/day); rabies (10-6,82CVS dilution); and test (10-6,82 CVS dilution and bufotenine, in the above-mentioned doses). Animals were observed daily for 21 days or until the 3rd stage of rabies infection. Twitch-tension and liposome studies were applied to understand the possible interaction of bufotenine with receptors, particularly acetylcholine. Results: Bufotenine was able to increase the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Rabies; Rabies therapy; Bufotenine. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992020000100303 Isolation and biochemical characterization of bradykinin-potentiating peptides from Bitis gabonica rhinoceros J. Venom. Anim. Toxins incl. Trop. Dis. Fucase,Tamara M.; Sciani,Juliana M.; Cavalcante,Ingrid; Viala,Vincent L.; Chagas,Bruno B.; Pimenta,Daniel C.; Spencer,Patrick J.. Abstract Background: Venoms represent a still underexplored reservoir of bioactive components that might mitigate or cure diseases in conditions in which conventional therapy is ineffective. The bradykinin-potentiating peptides (BPPs) comprise a class of angiotensin-I converting enzyme (ACE) inhibitors. The BPPs usually consist of oligopeptides with 5 to 13 residues with a high number of proline residues and the tripeptide Ile-Pro-Pro (IPP-tripeptide) in the C-terminus region and have a conserved N-terminal pyroglutamate residue. As a whole, the action of the BPPs on prey and snakebite victims results in the decrease of the blood pressure. The aim of this work was to isolate and characterize novel BPPs from the venom of Bitis gabonica rhinoceros.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Peptide; Hypotension; Viperinae. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100322 Registros recuperados: 2 Primeira ... 1 ... Última

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