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	Provedor de dados BJMBR (4) Autor Seguro,A.C. (4) Andrade,L. (2) Araujo,M. (1) Biagioni Santos,M.S. (1) Eira,M. (1) Hosaka,E.M. (1) Luque,A. (1) Sanches,T.R. (1) Santos,O.F.P. (1) Shimizu,M.H.M. (1) Vattimo,M.F.F. (1) Mais... Palavra-chave Acquired immunodeficiency syndrome (1) Acute kidney failure (1) Acute renal failure (1) Aminoglycoside (1) Artificial respiration (1) Drug toxicity (1) Glomerular filtration rate (1) HIV (1) Indinavir (1) Indomethacin (1) Kidney (1) Magnesium deficiency (1) Nephrotoxicity (1) Nitric oxide (1) Nonsteroidal anti-inflammatory drugs (1) Physiology (1) Rofecoxib (1) Water-electrolyte imbalance (1) Wistar rats (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Info:eu-repo/semantics/other (1) Ano 2010 (1) 2009 (1) 2006 (1) 2004 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Effect of cyclooxygenase inhibitors on gentamicin-induced nephrotoxicity in rats BJMBR Hosaka,E.M.; Santos,O.F.P.; Seguro,A.C.; Vattimo,M.F.F.. The frequent use of nonsteroidal anti-inflammatory drugs (NSAID) in combination with gentamicin poses the additional risk of nephrotoxic renal failure. Cyclooxygenase-1 (COX-1) is the main enzyme responsible for the synthesis of renal vasodilator prostaglandins, while COX-2 participates predominantly in the inflammatory process. Both are inhibited by non-selective NSAID such as indomethacin. Selective COX-2 inhibitors such as rofecoxib seem to have fewer renal side effects than non-selective inhibitors. The objective of the present study was to determine whether the combined use of rofecoxib and gentamicin can prevent the increased renal injury caused by gentamicin and indomethacin. Male Wistar rats (250-300 g) were treated with gentamicin (100 mg/kg body... Tipo: Info:eu-repo/semantics/article Palavras-chave: Indomethacin; Rofecoxib; Nonsteroidal anti-inflammatory drugs; Aminoglycoside; Acute renal failure. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000700006 Urinary NO3 excretion and renal failure in indinavir-treated patients BJMBR Eira,M.; Araujo,M.; Seguro,A.C.. Treatment with indinavir (IDV), a protease inhibitor, is frequently associated with renal abnormalities. We determined the incidence of renal failure (creatinine clearance <80 mL min-1 1.73 (m²)-1) in HIV patients treated with highly active antiretroviral therapy, including IDV, and investigated the possible mechanisms and risk factors of IDV nephrotoxicity. Thirty-six patients receiving IDV were followed for 3 years. All were assessed for age, body weight, duration of infection, duration of IDV treatment, sulfur-derivative use, total cholesterol, triglycerides, magnesium, sodium, potassium, creatinine, and urinalysis. We also determined renal function in terms of creatinine clearance, urine osmolality and fractional excretion of sodium, potassium, and... Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; Indinavir; Nephrotoxicity; Nitric oxide. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000800009 Hypomagnesemia is a risk factor for nonrecovery of renal function and mortality in AIDS patients with acute kidney injury BJMBR Biagioni Santos,M.S.; Seguro,A.C.; Andrade,L.. The objective of the present study was to determine the prevalence of electrolyte disturbances in AIDS patients developing acute kidney injury in the hospital setting, as well as to determine whether such disturbances constitute a risk factor for nephrotoxic and ischemic injury. A prospective, observational cohort study was carried out. Hospitalized AIDS patients were evaluated for age; gender; coinfection with hepatitis; diabetes mellitus; hypertension; time since HIV seroconversion; CD4 count; HIV viral load; proteinuria; serum levels of creatinine, urea, sodium, potassium and magnesium; antiretroviral use; nephrotoxic drug use; sepsis; intensive care unit (ICU) admission, and the need for dialysis. Each of these characteristics was correlated with the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Acquired immunodeficiency syndrome; Acute kidney failure; Water-electrolyte imbalance; Magnesium deficiency; Drug toxicity. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000300015 Glomerular filtration is reduced by high tidal volume ventilation in an in vivo healthy rat model BJMBR Luque,A.; Shimizu,M.H.M.; Andrade,L.; Sanches,T.R.; Seguro,A.C.. Mechanical ventilation has been associated with organ failure in patients with acute respiratory distress syndrome. The present study examines the effects of tidal volume (V T) on renal function using two V T values (8 and 27 mL/kg) in anesthetized, paralyzed and mechanically ventilated male Wistar rats. Animals were randomized into two groups of 6 rats each: V T8 (V T, 8 mL/kg; 61.50 ± 0.92 breaths/min; positive end-expiratory pressure, 3.0 cmH2O; peak airway pressure (PAW), 11.8 ± 2.0 cmH2O), and V T27 (V T, 27 mL/kg; 33.60 ± 1.56 breaths/min; positive end-expiratory pressure, none, and PAW, 22.7 ± 4.0 cmH2O). Throughout the experiment, mean PAW remained comparable between the two groups (6.33 ± 0.21 vs 6.50 ± 0.22 cmH2O). For rats in the V T27 group,... Tipo: Info:eu-repo/semantics/other Palavras-chave: Artificial respiration; Kidney; Physiology; Glomerular filtration rate; Wistar rats. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100017 Registros recuperados: 4 Primeira ... 1 ... Última

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