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| Gomes,Alcir Teixeira; Smania Júnior,Artur; Seidel,Cintia; Smania,Elza de Fátima Albino; Honda,Neli Kika; Roese,Fernanda Mesquita; Muzzi,Rozanna Marques. |
| In order to obtain new compounds with antibacterial activity, the derivatives 2,4-dihydroxy-6-methylbenzoic acid (orsellinic acid) and 2,4-dihydroxy-6-methylbenzoates (orsellinates) were obtained through alcoholyses of lecanoric acid. All these substances were tested against Gram-positive and Gram-negative bacteria by a microdilution method. Staphylococcus aureus, Xanthomonas campestris var. vesicatoria and Ralstonia solanacearum were most sensitive to n-propyl 2,4-dihydroxy-6-methylbenzoate, n-pentyl 2,4-dihydroxy-6-methylbenzoate and n-hexyl 2,4-dihydroxy-6-methylbenzoate with MIC (Minimal Inhibitory Concentration) values ranging from 62.5 to 7.8 µg×mL¹. These results showed that homologation in carbon chain may lead to compounds with more pronunced... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Orsellinates; Lecanoric acid; Orsellinic acid; Antibacterial activity. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822003000300002 |
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