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Rational design of diagnostic and vaccination strategies for tuberculosis BJID
Borsuk,Sibele; Seixas,Fabiana Kommling; Ramos,Daniela Fernandes; Mendum,Tom; McFadden,Johnjoe; Dellagostin,Odir.
The development of diagnostic tests which can readily differentiate between vaccinated and tuberculosis-infected individuals is crucial for the wider utilization of bacillus Calmette-Guérin (BCG) as vaccine in humans and animals. BCG_0092 is an antigen that elicits specific delayed type hypersensitivity reactions similar in size and morphological aspects to that elicited by purified protein derivative, in both animals and humans infected with the tubercle bacilli. We carried out bioinformatics analyses of the BCG_0092 and designed a diagnostic test by using the predicted MHC class I epitopes. In addition, we performed a knockout of this gene by homologous recombination in the BCG vaccine strain to allow differentiation of vaccinated from infected...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Gene knockout techniques; Clinical diagnosis; BCG vaccine.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100012
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