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	Provedor de dados Nature Precedings (1) Autor Byung-Young Park (1) Eun kyu Park (1) Hee Suk Lee (1) Hyunghee Lee (1) Jinmi Lee (1) Jong Cheon Hahm (1) Michung Yoon (1) Min-Young Kim (1) Seolwha Choi (1) Yeonhee Hong (1) Mais... Palavra-chave Biotechnology (1) Tipo do documento Manuscript (1) Ano 2009 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última The anti-angiogenic herbal composition Ob-X inhibits adipose tissue growth in obese mice Nature Precedings Min-Young Kim; Jong Cheon Hahm; Byung-Young Park; Hee Suk Lee; Eun kyu Park; Michung Yoon; Jinmi Lee; Yeonhee Hong; Seolwha Choi; Hyunghee Lee. Objective: The growth and development of adipose tissue are thought to be associated with angiogenesis and extracellular matrix remodeling. Since the composition of the herbal extract called Ob-X has been shown to have both anti-angiogenic and matrix metalloproteinase (MMP)-inhibiting activities, we hypothesized that growth of adipose tissue can be regulated by Ob-X. Materials and Methods: The effects of Ob-X on angiogenesis and extracellular matrix remodeling were measured using in vitro and ex vivo assays. The effects of Ob-X on adipose tissue growth were investigated with nutritionally obese mice. Results: Ob-X inhibited angiogenesis in a dose-dependent manner in the human umbilical vein endothelial cell (HUVEC) tube formation assay in vitro and the rat... Tipo: Manuscript Palavras-chave: Biotechnology. Ano: 2009 URL: http://precedings.nature.com/documents/2970/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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