|
|
|
|
|
Lauriane Cantin; Magalie Lenoir; Sarah Dubreucq; Fushia Serre; Caroline Vouillac; Serge H. Ahmed. |
Assessing the relative reward value of cocaine and how it changes with repeated use represents a long-standing goal in addiction research. Surprisingly, recent experimental research in rats – the most frequently used animal model in the field – suggests that the reward value of cocaine may in fact be relatively weak at least in the majority of individuals. Here, we provide strong additional evidence that confirms and extends the validity and generality of this research. Specifically, we demonstrate that no matter how heavy is past cocaine self-administration, most rats value cocaine poorly and readily decide to quit when offered the opportunity of making a different choice (i.e., drinking water sweetened with saccharin, an otherwise... |
Tipo: Manuscript |
Palavras-chave: Neuroscience; Pharmacology. |
Ano: 2009 |
URL: http://precedings.nature.com/documents/3738/version/1 |
| |
|
|
Serge H. Ahmed; George F. Koob. |
Cocaine does not only evoke intense rewarding sensations but also induces craving for more cocaine. This latter effect is especially obvious in addicted individuals and is thought to contribute together with other factors to trigger relapse after abstinence. Cocaine-induced craving can be studied in animals in the drug reinstatement model. In this model, responding for the drug (e.g., pressing a lever) is first extinguished by discontinuing drug reinforcement and then reinstated by drug priming (i.e., non-contingent re-exposure to the drug) or stress. Importantly, during reinstatement testing, responses continue to be unrewarded as during extinction and, therefore, reflect genuine drug seeking. Here we show that reinstatement of cocaine seeking can be... |
Tipo: Manuscript |
Palavras-chave: Neuroscience; Pharmacology. |
Ano: 2009 |
URL: http://precedings.nature.com/documents/2980/version/1 |
| |
|
|
|