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Genes and chromosomes: control of development Anais da ABC (AABC)
Serov,Oleg; Serova,Irina.
The past decade has witnessed immense progress in research into the molecular basis behind the developmental regulation of genes. Sets of genes functioning under hierarchical control have been identified, evolutionary conserved systems of genes effecting the cell-to-cell transmission of transmembrane signals and assigned a central role in morphogenesis have been intensively studied; the concept of genomic regulatory networks coordinating expression of many genes has been introduced, to mention some of the major breakthroughs. It should be noted that the temporal and tissue-specific parameters of gene expression are correctly regulated in development only in the context of the chromosome and that they are to a great extent dependent on the position of the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Epigenetic regulation; Developmental genes; Genetic networks; Variegated position effect; Chromosome territories; Organization of the interphase nucleus.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000300007
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