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| Muheem,Abdul; Shakeel,Faiyaz; Zafar,Sobiya; Jahangir,Mohammed Asadullah; Warsi,Musarrat Husain; Jain,Gaurav Kumar; Ahmad,Farhan Jalees. |
| ABSTRACT A novel, accurate, precise and economical stability indicating Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) method, was developed and validated for the quantitative determination of ubidecarenone (UDC) in bulk drug, UDC marketed formulation and UDC loaded cubosomes (CBMs) nanocarriers through Response surface methodology (RSM) design with three factors and three levels was performed to optimize the chromatographic variables followed by forced degradation studies of UDC were performed to detect degradation peak. RP-HPLC separation was achieved using mobile phase consisting of Acetonitrile:Tetrahydrofuran:Deionised water in the ratio 55:42:3 and a flow rate of 1.0 mL/min was optimized with a standard retention time (Rt) of 2.15... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: High Performance Liquid Chromatography/validation/stability; Response surface methodology (RSM); Ubidecarnenone (UDC)/evaluation. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400614 |
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