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	Provedor de dados Nature Precedings (3) Autor Sher Singh (3) Alan Scott (2) Anne Jedlicka (2) August Louis Bourgeois (2) Nathan Wolfe (2) Wan-Chung(Wan-Jiung) Hu (2) Betty A. Wu-Hsieh (1) Chuan-Liang Kao (1) Wan-Jiung(Wan-Chung) Hu (1) Yu-Ting Yen (1) Mais... Palavra-chave Bioinformatics (3) Genetics & Genomics (3) Immunology (3) Microbiology (3) Tipo do documento Manuscript (3) Ano 2011 (3) País United Kingdom (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Microarray Analysis of PBMC after Plasmodium falciparum Infection: Molecular Insights into Disease Pathogenesis Nature Precedings Wan-Chung(Wan-Jiung) Hu; Alan Scott; Nathan Wolfe; Sher Singh; Anne Jedlicka; August Louis Bourgeois. Our laboratory’s previous microarray analysis of subjects with Plasmodium falciparum revealed up-regulation of Toll-like receptor, NF-kB, TNF-α, IFN-γ, IL-1β, p38 MAPK, and MHC molecules. We performed further time-course microarray analysis focusing on malaria pathogenesis by using peripheral leukocytes as a cellular model. We found up-regulation of coagulation-related genes (SERPINB2, thrombomodulin, thrombospondin), heat shock proteins, glycolytic enzymes, glucose transporters, and vacuolar H+-ATPases in acute febrile malaria. In early malaria, prior to detectable parasitemia, CD36 and ICAM1 were up-regulated. During acute malaria, a correlation was observed between IL-1ß and heat shock proteins,... Tipo: Manuscript Palavras-chave: Genetics & Genomics; Immunology; Microbiology; Bioinformatics. Ano: 2011 URL: http://precedings.nature.com/documents/5929/version/1 Human Immune Responses to Plasmodium falciparum infection: Molecular Evidence for a Suboptimal THαβ(TH9) and TH17 Bias over Ideal and Effective Traditional TH1 Immunity Nature Precedings Wan-Chung(Wan-Jiung) Hu; August Louis Bourgeois; Nathan Wolfe; Sher Singh; Anne Jedlicka; Alan Scott. Using microarray analysis, we showed up-regulation of Toll-like receptors 1,2,4,7,8, NF-[kappa][BETA], TNF-[alpha], p38-MAPK and MHC molecules in human peripheral blood mononuclear cells following infection with Plasmodium falciparum. We report herein further studies based on time-course microarray analysis with a focus on malaria-induced host immunity. Results show that in early malaria; selected immunity-related genes were up-regulated including alpha, beta, and gamma interferon related genes, as well as genes of IL-15, CD36, chemokines (CXCL10, CCL2, S100A8/9, CXCL9, and CXCL11), TRAIL and IgG Fc receptors. During acute febrile malaria, up-regulated genes included alpha, beta, and gamma interferon related genes, IL-8, IL-1[beta], IL-10 downstream... Tipo: Manuscript Palavras-chave: Genetics & Genomics; Immunology; Microbiology; Bioinformatics. Ano: 2011 URL: http://precedings.nature.com/documents/5930/version/1 SARS-CoV Regulates Immune Function-Related Gene Expressions in Human Monocytic Cells Nature Precedings Wan-Jiung(Wan-Chung) Hu; Yu-Ting Yen; Sher Singh; Chuan-Liang Kao; Betty A. Wu-Hsieh. Background: Severe Acute Respiratory Syndrome (SARS) is characterized by acute respiratory distress (ARDS) and pulmonary fibrosis, and the monocyte/macrophage is the key player in the pathogenesis of SARS.
 
Methods: In this study, we compared the transcriptional profiles of SARS coronavirus (SARS-CoV) infected monocytic cells against that infected by coronavirus 229E (CoV-229E). Total RNA was extracted from infected DC-SIGN transfected monocytes (THP-1-DC-SIGN) at 6 and 24 h after infection and the gene expression was profiled by oligonucleotide-based microarray. 

Results: Analysis of immune-related gene expression profiles showed that 24 h after SARS-CoV infection, (i)... Tipo: Manuscript Palavras-chave: Genetics & Genomics; Immunology; Microbiology; Bioinformatics. Ano: 2011 URL: http://precedings.nature.com/documents/5908/version/1 Registros recuperados: 3 Primeira ... 1 ... Última

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