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	Provedor de dados BJID (1) Autor Ariffin,Tg Ahmad Akram Tg Mohd (1) Deris,Zakuan Zainy (1) Mohamad,Suharni (1) Shueb,Rafidah Hanim (1) Yusoff,Nik Khairulddin (1) Palavra-chave Children (1) HIV-1 subtype (1) Resistance mutation (1) Tipo do documento Info:eu-repo/semantics/other (1) Ano 2012 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Assessing subtypes and drug resistance mutations among HIV-1 infected children who failed antiretroviral therapy in Kelantan, Malaysia BJID Mohamad,Suharni; Deris,Zakuan Zainy; Yusoff,Nik Khairulddin; Ariffin,Tg Ahmad Akram Tg Mohd; Shueb,Rafidah Hanim. Antiretroviral (ARV) therapy has dramatically reduced morbidity and mortality in human immunodeficiency virus 1 (HIV-1) infected children. However, development of ARV resistance in these children is a major public health problem due to lack of availability of and access to new drugs. This study was conducted in order to identify circulating HIV subtypes and recombinant forms and evaluate the drug resistance mutation patterns in 18 HIV-1 infected children failing ARV treatment in Kelantan, Malaysia. Genotyping for codon 1-99 of protease (PR) and 1-250 of reverse transcriptase (RT) were performed by polymerase chain reaction (PCR) amplification and DNA sequencing. Subsequently, these were phylogenetically analyzed to determine the subtypes. CRF33_01B (44.4%)... Tipo: Info:eu-repo/semantics/other Palavras-chave: HIV-1 subtype; Resistance mutation; Children. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300012 Registros recuperados: 1 Primeira ... 1 ... Última

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