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Radiolabelled cytokines for imaging chronic inflammation BABT
Signore,Alberto; D'Alessandria,Calogero; Annovazzi,Alessio; Scopinaro,Francesco.
Diagnosis and particularly follow-up of chronic inflammatory disorders could be often difficult in clinical practice. Indeed, traditional radiological techniques reveal only structural tissue alterations and are not able to monitor functional changes occurring in tissues affected by chronic inflammation. The continuous advances in the knowledge of the pathophysioloy of chronic disorders, combined with the progress of radiochemistry, led to the development of new specific radiolabelled agents for the imaging of chronic diseases. In this scenario, cytokines, due to their pivotal role in such diseases, represent good candidates as radiopharmaceuticals.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiolabelled cytokines; Chronic inflammation; Imaging.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500004
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Radiopharmaceuticals for imaging chronic lymphocytic inflammation BABT
Malviya,Gaurav; Vries,Erik F.J. de; Dierckx,Rudi A.; Signore,Alberto.
In the last few decades, a number of radiopharmaceuticals for imaging inflammation have been proposed that differ in their specificity and mechanism of uptake in inflamed foci as compared to the traditional inflammation imaging agents. Radiolabelled cytokines represent a reliable tool for the preclinical diagnosis of chronic inflammatory processes, even before anatomical and functional changes occur in affected tissues. Moreover, the introduction of radiolabelled monoclonal antibodies and sophisticated technique like PET/CT now make the field of inflammation imaging highly specific and accurate. In this review, different approaches of the established and experimental radiopharmaceuticals for imaging of chronic inflammation are discussed.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiopharmaceuticals; Inflammation; Molecular Imaging.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600002
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