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| Silva,Ellen Cristina Costa da; Amorim,Rodrigo César das Neves; Tadei,Wanderli Pedro; Pohlit,Adrian Martin. |
| Quassinoids neosergeolide and isobrucein B, obtained from Picrolemma sprucei, have proven in vitro antitumor, antimalarial, anthelminthic, cytotoxic, insecticide and leishmanicidal activities. There is interest in the in vivo pharmacological study of these natural compounds and their semi-synthetic derivatives, however, the quantities obtained in previous extraction processes have been shown to be a limiting factor for continuation of these studies. Herein, we describe a method for obtaining grams of these quassinoids whose purification relies only on recrystallization. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Caferana; Simaroubaceae; Quassinoid; Recrystallization. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672009000100026 |
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| Nunomura,Rita de Cássia Saraiva; Silva,Ellen Cristina Costa da; Oliveira,Denilson Ferreira; Garcia,Adriana Mello; Boeloni,Jankerle Neves; Nunomura,Sergio Massayoshi; Pohlit,Adrian Martin. |
| 1300 ppm (1.3 g / L), water and ethanol extracts prepared from stems or roots of Picrolemma sprucei Hook. f. were lethal (85-90 % mortality) in vitro to Haemonchus contortus (Barber Pole Worm) larvae, a gastrointestinal nematode parasite found in domestic and wild ruminants. Neosergeolide and isobrucein B were isolated in 0.0083 and 0.0070 % yield from dry, ground P. sprucei stems (0.89 kg). Neosergeolide, isobrucein B and the anthelmintic drug standard levamisole all caused comparable mortality rates (68-77 %) in vitro to H. contortus at similar concentrations (81-86 ppm). The anthelmintic activity of P. sprucei infusions (teas), alcohol extracts, and neosergeolide and isobrucein B, has therefore been demonstrated for the first time. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Picrolemma pseudocoffea Ducke; Haemonchus contortus; Neosergeolide; Isobrucein B; Caferana. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672006000300006 |
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