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| Faiões,Viviane dos Santos; Frota,Lívia C. R. M. da; Cunha-Junior,Edézio Ferreira; Barcellos,Julio C. F.; Silva,Thayssa Da; Daher Netto,Chaquip; Da-Silva,Silvia Amaral Gonçalves; Silva,Alcides J. M. da; Costa,Paulo R. R.; Torres-Santos,Eduardo Caio. |
| Abstract Background: Despite the development of new therapies for leishmaniasis, among the 200 countries or territories reporting to the WHO, 87 were identified as endemic for Tegumentary Leishmaniasis and 75 as endemic for Visceral Leishmaniasis. The identification of antileishmanial drug candidates is essential to fill the drug discovery pipeline for leishmaniasis. In the hit molecule LQB-118 selected, the first generation of pterocarpanquinones was effective and safe against experimental visceral and cutaneous leishmaniasis via oral delivery. In this paper, we report the synthesis and antileishmanial activity of the second generation of pterocarpanoquinones. Methods: The second generation of pterocarpanquinones 2a-f was prepared through a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leishmania; Pterocarpanquinone; LQ-118; Phenotypic assay; Leishmaniasis; Drug discovery; Neglected diseases. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100325 |
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